Complex Systems Biology approaches are here considered from the viewpoint of Robert Rosen’s (M,R)-systems, Relational Biology and Quantum theory, as well as from the standpoint of computer modeling. Realizability and Entailment of (M,R)-systems are two key aspects that relate the abstract, mathematical world of organizational structure introduced by Rosen to the various physicochemical structures of complex biological systems. Their importance for understanding biological function and life itself, as well as for designing new strategies for treating diseases such as cancers, is (...) pointed out. The roles played by multiple metastable states in the “continuous uphill flow of Life” supported through internal bioenergetic processes that are coupled to essential inflows are also discussed in relation to dynamic realizations of (M,R)-systems. Furthermore, the roles played by the underlying, many-valued, quantum logics and symbolic computations for ultra-complex biological systems are also briefly discussed. (shrink)

A categorical, higher dimensional algebra and generalized topos framework for Łukasiewicz–Moisil Algebraic–Logic models of non-linear dynamics in complex functional genomes and cell interactomes is proposed. Łukasiewicz–Moisil Algebraic–Logic models of neural, genetic and neoplastic cell networks, as well as signaling pathways in cells are formulated in terms of non-linear dynamic systems with n-state components that allow for the generalization of previous logical models of both genetic activities and neural networks. An algebraic formulation of variable ‘next-state functions’ is extended to a Łukasiewicz–Moisil (...) Topos with an n-valued Łukasiewicz–Moisil Algebraic Logic subobject classifier description that represents non-random and non-linear network activities as well as their transformations in developmental processes and carcinogenesis. The unification of the theories of organismic sets, molecular sets and Robert Rosen’s (M,R)-systems is also considered here in terms of natural transformations of organismal structures which generate higher dimensional algebras based on consistent axioms, thus avoiding well known logical paradoxes occurring with sets. Quantum bionetworks, such as quantum neural nets and quantum genetic networks, are also discussed and their underlying, non-commutative quantum logics are considered in the context of an emerging Quantum Relational Biology. (shrink)

A categorical, higher dimensional algebra and generalized topos framework for Łukasiewicz–Moisil Algebraic–Logic models of non-linear dynamics in complex functional genomes and cell interactomes is proposed. Łukasiewicz–Moisil Algebraic–Logic models of neural, genetic and neoplastic cell networks, as well as signaling pathways in cells are formulated in terms of non-linear dynamic systems with n-state components that allow for the generalization of previous logical models of both genetic activities and neural networks. An algebraic formulation of variable ‘next-state functions’ is extended to a Łukasiewicz–Moisil (...) Topos with an n-valued Łukasiewicz–Moisil Algebraic Logic subobject classifier description that represents non-random and non-linear network activities as well as their transformations in developmental processes and carcinogenesis. The unification of the theories of organismic sets, molecular sets and Robert Rosen’s (M,R)-systems is also considered here in terms of natural transformations of organismal structures which generate higher dimensional algebras based on consistent axioms, thus avoiding well known logical paradoxes occurring with sets. Quantum bionetworks, such as quantum neural nets and quantum genetic networks, are also discussed and their underlying, non-commutative quantum logics are considered in the context of an emerging Quantum Relational Biology. (shrink)

In his lucid paper “The Objectivity of History” Professor Pass more poses the problem of history's objectivity and seeks to find out in what the objectivity of history might consist. In this note I wish only to criticize his presentation of Popper's views . I think Pass more's failure to report Popper's views correctly causes him to overlook the striking similarity between Popper's conclusion and his own.

Saunders & van Brakel's criticism of Berlin & Kay's methodology misunderstands the fact that scientific hypotheses are tested by generating new, replicable data with novel explanatory power. Thus, although Berlin and Kay studied differences in colour words between languages, the same patterns are also present in colour word usage within languages, in a range of literary and other textual databases.

Colour word usage within languages follows the same ordering as that proposed by Berlin and Kay between languages. This provides additional validation and support for Berlin and Kay's schema.

Although there are some common underlying mechanisms for many nonhuman behavioural asymmetries, the evidence at present is not compelling for commonalities in cerebral organisation across vertebrates. Phylogenetic analysis of detour behaviour in fish suggests that more closely related species are not particularly similar in the direction of turning; contingency and demands of ecological niches may better explain such asymmetries.

John Wyclif’s rejection of the doctrine of transubstantiation has received a considerable amount of attention over the last six centuries. To this day scholars continue to reflect upon it, offering a variety of perspectives on Wyclif’s rationale. This study specifically considers the question in connection with Wyclif’s opposition to the more radical element in the fourteenth-century schools. Vehemently opposed to the reckless application of logical-grammatical methods which had led some to question of the truth of biblical propositions, Wyclif would insist (...) that within Scripture there exist no contradictions; its veracity can never be doubted. And most importantly, Christ himself is truthful; he cannot lie. Hence, when Christ spoke the words «Hoc est corpus meum», he was not positing a deception. (shrink)

Preoccupation with LTP as a putative memory mechanism may have retarded the consideration of pathological modulation of synaptic plasticity in clinical disorders where memory dysfunction is not a primary feature. Encouraged by Shors & Matzel's review, we consider the relationship between stress, synaptic plasticity, and depressive disorder.

In this exciting Handbook, Ian Jarvie and Jesús Zamora-Bonilla have put together a wide-ranging and authoritative overview of the main philosophical currents and traditions at work in the social sciences today. Starting with the history of social scientific thought, this Handbook sets out to explore that core fundamentals of social science practice, from issues of ontology and epistemology to issues of practical method. Along the way it investigates such notions as paradigm, empiricism, postmodernism, naturalism, language, agency, power, culture, and causality.